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1 article(s) from Vázquez, Olalla

In search of visible-light photoresponsive peptide nucleic acids (PNAs) for reversible control of DNA hybridization

Lei Zhang,
Greta Linden and
Olalla Vázquez

Beilstein J. Org. Chem. 2019, 15, 2500–2508, doi:10.3762/bjoc.15.243

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Figure 1: A) Structure of the pioneering azobenzene-modified DNA [16] compared with the photoswitchable PNA struc...

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Scheme 1: Solid-phase synthesis of photoswitchable PNAs; Aeg = N-(2-aminoethyl)glycine, Bhoc = benzhydryloxyc...

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Figure 2: Time-dependent conversion to the thermodynamically stable isomer of PNA₁₂(oF₄Azo) (3; green triangl...

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Figure 3: A) Melting curves of a 1 µM duplex solution in phosphate buffer (10 mM NaH₂PO₄, 150 mM NaCl, pH 7.4...

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Figure 4: Outline of the displacement assay principle, in which a photoswitchable PNA probe (blue) hybridizes...

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Figure 5: Time-dependent fluorescence signals from two independent experiments at 520 nm of 0.75 μM FAM/BHQ-d...

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Published 22 Oct 2019

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